Nadine Nagy, Gernot Kaber, Mike Kratochvil and Koshika Yadava recent ly published their work entitled “Hyaluronan content governs tissue stiffness in pancreatic islet inflammation” in the Journal of Biological Chemistry. This study is the first to measure the mechanical properties of an inflamed tissue and the first to link changes in tissue stiffness to hyaluronan content. Because tissue stiffness impacts insulin production by Beta cells, these findings may help explain how islet inflammation impacts glycemic control.