Liz Burgener, Carlos Milla, and the Bollyky Lab published in Science Translational Medicine

Hot off the presses – the next chapter in how filamentous phage affect bacterial infections in people.   We report that Pf phage are associated with antibiotic resistance and poor outcomes in Cystic Fibrosis (CF) lung infections.  These findings build on our previous report that filamentous phage serve as structural elements in biofilms and can prevent diffusion of some antibiotics (see PMID:26567508).  Congratulations to Liz, Carlos Milla, and our collaborators Pat Secor, Rasmus Marvig, Helle Johansen, Elio Rossi, Søren Molin and everyone in the Bollyky Lab and the Stanford CF Center who made this happen. Check it out here: DOI: 10.1126/scitranslmed.aau9748Schematic

Jolien Sweere and the Bollyky Lab published in Science

Just out in Science magazine, we report that phage PROMOTE bacterial infections by triggering maladaptive anti-viral responses in human cells and suppressing anti-bacterial ones. Pf, a phage produced by the bacteria Pseudomonas aeruginosa is taken up by human cells at sites of infection and triggers TLR3 and TRIF mediated suppression of phagocytosis and TNF production.  Conversely, a vaccine directed against these phage was protective against these same bacterial infections.  Congratulations especially to the lead author Jolien Sweere but also Jonas Van Belleghem, Medea Popescu, Christiaan De Vries, Pat Secor, Gina Suh, Sundeep Keswani, and the rest of our lab members and collaborators who contributed to this work! Check it out here: http://science.sciencemag.org/content/363/6434/eaat9691.

Video of Pf bacteriophage (green) within a human cell (actin = purple, nucleus = purple).

Dr. Suh Moving to The Mayo Clinic

Dr. Gina Suh isIMG_0690 leaving Stanford to establish a clinical research program at The Mayo Clinic in Rochester, MN. Her work there will focus on skin, joint, and orthopedic infections with a special emphasis on bacteriophage therapy.  At Stanford, Gina has been an outstanding colleague and collaborator, a wonderful mentor to innumerable fellows and students, and a good friend. On behalf of everyone in Team Phage, The Bollyky Lab, and the Stanford University Division of Infectious Diseases, we  wish Gina and Colin good luck at Mayo and hope they come back and visit us sometimes (Lab Holiday party 2019?). May the Phage be with you Gina!