Hot off the presses – the next chapter in how filamentous phage affect bacterial infections in people. We report that Pf phage are associated with antibiotic resistance and poor outcomes in Cystic Fibrosis (CF) lung infections. These findings build on our previous report that filamentous phage serve as structural elements in biofilms and can prevent diffusion of some antibiotics (see PMID:26567508). Congratulations to Liz, Carlos Milla, and our collaborators Pat Secor, Rasmus Marvig, Helle Johansen, Elio Rossi, Søren Molin and everyone in the Bollyky Lab and the Stanford CF Center who made this happen. Check it out here: DOI: 10.1126/scitranslmed.aau9748
Just out in Science magazine, we report that phage PROMOTE bacterial infections by triggering maladaptive anti-viral responses in human cells and suppressing anti-bacterial ones. Pf, a phage produced by the bacteria Pseudomonas aeruginosa is taken up by human cells at sites of infection and triggers TLR3 and TRIF mediated suppression of phagocytosis and TNF production. Conversely, a vaccine directed against these phage was protective against these same bacterial infections. Congratulations especially to the lead author Jolien Sweere but also Jonas Van Belleghem, Medea Popescu, Christiaan De Vries, Pat Secor, Gina Suh, Sundeep Keswani, and the rest of our lab members and collaborators who contributed to this work! Check it out here: http://science.sciencemag.org/content/363/6434/eaat9691.
Video of Pf bacteriophage (green) within a human cell (actin = purple, nucleus = purple).
Interested in bacteriophage / immune interactions? The Bollyky Lab at Stanford University is looking for a post-doctoral fellow with expertise in molecular biology and microbiology. If interested please send a CV and cover letter to Paul at firstname.lastname@example.org.
Dung, a technician in the Lab from 2018-2019, is leaving us to begin graduate school in the doctoral program in Biomedical Sciences and Engineering (PBSE) at the University of California Santa Cruz. She will be pursuing research in the Molecular, Cell and Developmental Biology (MCD) track there. Good luck Dung! We’ll miss you!
Michelle, an undergraduate member of the lab, recently received the J.E. Wallace Sterling Award for Scholastic Achievement. This award is given annually by Stanford University to the top graduating seniors. Along with Dr. Bollyky, Michelle’s high school mentor Dr. Roma Jain also came for the award ceremony. Go Michelle!! You Rock!
Dr. Gina Suh is leaving Stanford to establish a clinical research program at The Mayo Clinic in Rochester, MN. Her work there will focus on skin, joint, and orthopedic infections with a special emphasis on bacteriophage therapy. At Stanford, Gina has been an outstanding colleague and collaborator, a wonderful mentor to innumerable fellows and students, and a good friend. On behalf of everyone in Team Phage, The Bollyky Lab, and the Stanford University Division of Infectious Diseases, we wish Gina and Colin good luck at Mayo and hope they come back and visit us sometimes (Lab Holiday party 2019?). May the Phage be with you Gina!
Congratulations to Liz for winning the award for best clinical research at the 2018 Respiratory Disease Young Investigators Forum. Liz presented her research on bacteriophage and the pathogenesis of lung infections in Cystic Fibrosis. Go Liz!