Publications

2022

  • Karius Plasma Next Generation Sequencing Cell-free Pathogen DNA Test: Plasma Microbial Cell-free DNA Next Generation Sequencing in the Diagnosis and Management of Febrile Neutropenia. E Benamu, K Gajurel, JN Anderson, T Lieb, CA Gomez, H Seng, R Aquino, D Hollemon, D Hong, T Blauwkamp, M Kertesz, L Blair, PL Bollyky, BC Medeiros, S Coutre, S Zompi, JG Montoya, S Deresinski. CLINICAL INFECTIOUS DISEASES 2021 Apr 19:ciab324. doi: 10.1093/cid/ciab324. PMID: 33870413.
  • A Filamentous Bacteriophage Protein Inhibits Type IV Pili to Prevent Superinfection of Pseudomonas aeruginosa. Schmidt AK, Fitzpatrick AD, Schwartzkopf CM, Faith DR, Jennings LK, Coluccio A, Hunt DJ, Michaels LA, Dorward DW, Wachter J, Rosa PA, Bollyky PL, Maxwell KL, and Secor PR, mBIO. 2022. Jan 18;13(1):e0244121. doi: 10.1128/mbio.02441-21. PMID: 35038902 
  • Oral hymecromone decreases hyaluronan in human study participants. Rosser JI, Nagy N, Goel R, Kaber G, Demirdjian S, Saxena J, Bollyky JB, Frymoyer AR, Pacheco-Navarro AE, Burgener EB, Rajadas J, Wang Z, Arbach O, Dunn CE, Kalinowski A, Milla CE, Bollyky PL. JOURNAL OF CLINICAL INVESTIGATION 2022 May 2;132(9):e157983. doi: 10.1172/JCI157983. PMID: 35499083

2021

  • Filamentous Bacteriophages and the Competitive Interaction between Pseudomonas aeruginosa Strains under Antibiotic Treatment: a Modeling Study. Pourtois JD, Kratochvil MJ, Chen Q, Haddock NL, Burgener EB, De Leo GA, Bollyky PL. mSYSTEMS. 2021 Jun. PMID: 34156288
  • Bacteriophages and the Immune System. Popescu M, Van Belleghem JD, Khosravi A, Bollyky PL. ANNU REV VIROL. 2021 May. PMID: 34014761
  • Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media. Khomtchouk KM, Joseph LI, Khomtchouk BB, Kouhi A, Massa S, Xia A, Koliesnik I, Pletzer D, Bollyky PL, Santa Maria PL. NPJ BIOFILMS MICROBIOMES. 2021 Apr. PMID: 33824337
  • Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity. Cano EJ, Caflisch KM, Bollyky PL, Van Belleghem JD, Patel R, Fackler J, Brownstein MJ, Horne B, Biswas, Henry M, Malagon F, Lewallen DG, Suh GA. CLINICAL INFECTIOUS DISEASES. 2020 Jul. PMID: 32699879
  • Tolerant Small-colony Variants Form Prior to Resistance Within a Staphylococcus aureus Biofilm Based on Antibiotic Selective Pressure. R Manasherob, JA Mooney, DW Lowenberg, PL Bollyky, DF Amanatullah. CLINICAL ORTHOPEDIC RESEARCH 2021 Apr 7. doi: 10.1097/CORR.0000000000001740. PMID: 33835090.
  • Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, Meyer E, Piehler J, Leonard WJ, Garcia KC. eLIFE. 2021 May. PMID: 34003116
  • Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection. Marshall PL, Nagy N, Kaber G, Barlow GL, Ramesh A, Xie BJ, Linde MH, Haddock NL, Lester CA, Tran QL, de Vries CR, Hargil A, Malkovskiy AV, Gurevich I, Martinez HA, Kuipers HF, Yadava K, Zhang X, Evanko SP, Gebe JA, Wang X, Vernon RB, de la Motte C, Wight TN, Engleman EG, Krams SM, Meyer EH, Bollyky PL. MATRIX BIOLOGY. 2021 Feb. PMID: 33290836
  • Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice. Nagy N, Kaber G, Kratochvil MJ, Kuipers HF, Ruppert SM, Yadava K, Yang J, Heilshorn SC, Long SA, Pugliese A, Bollyky PL. DIABETOLOGIA. 2021 Jan. PMID: 33125521
  • The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice. N Nagy, G Kaber, NL Haddock, A Hargil, J Rajadas, SV Malhotra, MA Unger, AR Frymoyer, PL Bollyky. In “Hyaluronan Structure, Biology and Biotechnology”. Springer Press (2021).
  • Interleukin-10 Producing T Lymphocytes Attenuate Dermal Scarring. WD Short, X Wang, H Li, L Yu, A Kaul, G Calderon, J Gilley, PL Bollyky, S Balaji, SG Keswani. *ANNALS OF SURGERY. Oct 1;274(4):627-636. doi: 10.1097/SLA.0000000000004984. PMID: 34506318.
  • Dynamic Light Scattering Microrheology for Soft and Living Materials. PC Cai, BA Krajina, MJ Kratochvil, L Zou, A Zhu, EB Burgener, PL Bollyky, CE Milla, MJ Webber, AJ Spakowitz, SC Heilshorn. SOFT MATTER. 2021 Feb 21;17(7):1929-1939. doi: 10.1039/d0sm01597k. PMID: 33427280
  • Skin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation. Steen EH, Short WD, Li H, Parikh UM, Blum A, Templeman N, Nagy N, Bollyky PL, Keswani SG, Balaji S.  DRUG DELIVERY 2021 Dec;28(1):422-432. doi: 10.1080/10717544.2021.1886376. PMID: 33605181
  • Congenital Heart Disease: An Immunological Perspective. KL Singampalli, E Jui, K Shani, BY Ning, JP Connell, RK Birla, PL Bollyky, CA Caldarone, SG Keswani, KJ Grande-Allen. FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021 Aug 9;8:701375. doi: 10.3389/fcvm.2021.701375. eCollection 2021. PMID: 34434978
  • The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease. Jui E, Singampalli KL, Shani K, Ning Y, Connell JP, Birla RK, Bollyky PL, Caldarone CA, Keswani SG, Grande-Allen KJ. FRONTIERS IN CARDIOVASCULAR MEDICINE.2021 Jul 27;8:701224. doi: 10.3389/fcvm.2021.701224. eCollection 2021. PMID: 34386532

2020

  • Phages in vaccine design and immunity; mechanisms and mysteries. de Vries CR, Chen Q, Demirdjian S, Kaber G, Khosravi A, Liu D, Van Belleghem JD, Bollyky PL. CURR OPINION IN BIOTECHNOLOGY. 2020 Dec. PMID: 33316575
  • Pf bacteriophage and their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic Infections. Secor PR, Burgener EB, Kinnersley M, Jennings LK, Roman-Cruz V,  Popescu M, Van Belleghem JD, Haddock N, Copeland C,  Michaels LM,  de Vries CD, Chen Q, Pourtos J,  Wheeler TJ ,Milla CE,  and Bollyky PL. FRONTIERS IN IMMUNOLOGY. 2020 Feb. PMID: 32153575
  • A Novel Mouse Model of Chronic Suppurative Otitis Media and its Use in Preclinical Evaluation of Antibiotics. Khomtchouk KM, Kouhi A, Xia A, Bekale LA, Massa SM, Sweere JM, Pletzer D, Hancock RE, Bollyky PL, Santa Maria PL.. SCIENCE ADVANCES. 2020 Aug. PMID: 32851190
  • Methods for Extraction and Detection of Bacteriophage DNA from the Sputum of Patients with Cystic Fibrosis. Burgener, PR Secor, MC Tracy, JM Sweere, EM Bik, CE Milla, PLBollyky. PHAGE 2020 Jun 1;1(2):100-108. doi: 10.1089/phage.2020.0003. PMID: 32626852.
  • Hyaluronan is abundant in COVID-19 respiratory secretions. Kaber G, Kratochvil MJ, Burgener EB, Peltan EL, Barlow G, Yang S, Nicolls MR, de Jesus Perez V, Rosser JI, Wardle AJ, Kalinowski A, Ozawa MG, Regula DP, Nagy N, Heilshorn SC, Milla CE, Rogers AJ, Bollyky PL.  JCI INSIGHT
  • The immune response to chronic Pseudomonas aeruginosa wound infection in immune-competent mice. JM Sweere, H Ishak, V Sunkari, MS Bach, R Manasherob,K Yadava, SM Ruppert, CK Sen, S Balaji, SG Keswani, PR Secor, and PL Bollyky. ADVANCES IN WOUND CARE. 2020 Feb 1;9(2):35-47. doi: 10.1089/wound.2019.1039. PMID:31903297
  • A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection. CR de Vries, JM Sweere, H Ishak, V Sunkari, MS Bach, R Manasherob, and PL Bollyky. JOVE.(156), e60599, doi:10.3791/60599 (2020).
  • The Rationale for Using Bacteriophage to Treat and Prevent Periprosthetic Joint Infections. JD Van Belleghem, R Manasherob, R Międzybrodzki,  P Rogoz, A Górski, GA Suh, PL Bollyky and D Amanatullah.  FRONTIERS IN IMMUNOLOGY. 2020 Dec 21;11:591021. doi: 10.3389/fmicb.2020.591021. PMID: 33408703
  • The Role of an IL-10/Hyaluronan Axis in Dermal Wound Healing. KL Singampalli, S Balaji, X Wang, UM  Parikh, A Kaul, J Gilley, RK Birla, PL Bollyky, SG Keswani. FRONTIERS IN CELLULAR AND DEVELOPMENTAL BIOLOGY. 8:636. doi: 10.3389/fcell.2020.00636. PMID: 32850791
  • The Role of the Anti-Inflammatory Cytokine IL-10 in Tissue Fibrosis. E Steen, X Wang, S Balaji, MJ Butte, PL Bollyky, SG Keswani. ADVANCES IN WOUND CARE 2020.184-198 doi.org/10.1089/wound.2019.1032. PMID: 32117582
  • The Heparan Sulfate Mimetic PG545 polarizes T-cell responses towards Foxp3+ Treg. Koliesnik IO, Kuipers HF, Medina CO, Zihsler S, Liu D, Van Belleghem JD, Bollyky PL. FRONTIERS IN IMMUNOLOGY. 2020 Feb. PMID: 32117279
  • Involvement of hyaluronan in T cell-mediated autoimmune responses to transplanted islets. JA Gebe, MD Gooden, G Workman, N Nagy, PL Bollyky, TN Wight, RB Vernon. MATRIX BIOLOGY. 2020 Dec 30;9:100052. doi: 10.1016/j.mbplus.2020.100052. PMID: 33718858.
  • High Molecular Weight Hyaluronan Variants Attenuate Tubulointerstitial Scarring in Kidney Injury. X Wang, S Balaji, EH Steen, AJ Blum, H Li, CK Chan, SR Mason, T Lu, MM Rae, PF Austin, TN Wight, PL Bollyky, J Cheng, SG Keswani. JCI INSIGHT. 2020 May 12. pii: 136345. doi: 10.1172/jci.insight.136345. PMID:32396531

2019

  • Filamentous Bacteriophage Suppress Clearance of Bacterial Infection. JM Sweere, J Van Bellegehem, H Ishak, MS Bach, M Popescu, V Sunkari, G Kaber, R Manasherob,GA Suh, X Cao,CR De Vries, DN Lam, PL Marshall, M Birukova, E Katznelson, DV Lazzareschi, S Balaji, S Keswani, TR Hawn, PR Secor, and PL Bollyky.. SCIENCE. (2019) 363, 6434, 1416. DOI: 10.1126/science.aat9691
  • Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in Cystic Fibrosis. EB Burgener, JM Sweere, MS Bach, PR Secor, N Haddock, LK Jennings, RL Marvig, HK Johansen, E Rossi, X Cao, L Tian, L Nedelec, S Molin, PL Bollyky* and CE Milla*  SCIENCE TRANSLATIONAL MEDICINE. 17 Apr 2019: Vol. 11, Issue 488, eaau9748 DOI: 10.1126/scitranslmed.aau9748   *co-senior authors
  • The innate sense of bacteriophages. Bollyky PL, Secor PR. CELL HOST & MICROBE. 2019 Feb 13;25(2):177-179. doi: 10.1016/j.chom.2019.01.020.
  • Macrophages and innate immune memory against Staphylococcus skin infections. Van Belleghem JD and Bollyky PLPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES.
  • Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System. Van Belleghem JD, Dąbrowska K, Vaneechoutte M, Barr JJ, Bollyky PL. VIRUSES. 2018 Dec 25;11(1). pii: E10. doi: 10.3390/v11010010.
  • The Immune Response to Chronic Pseudomonas aeruginosa Wound Infection in Immunocompetent Mice. JM Sweere, H Ishak, V Sunkari, MS Bach, R Manasherob, K Yadava, SM Ruppert, CK Sen, S Balaji, SG Keswani, PR Secor, and PL Bollyky.  ADVANCES IN WOUND CARE.  2019 6 Aug 2019. doi.org/10.1089/wound.2019.1039
  • Pf4 bacteriophage produced by Pseudomonas aeruginosa inhibits Aspergillus fumigatus metabolism via iron sequestration. Penner, JC., Ferreira, JA, Secor, PR, Sweere, JM, Birukova, M, Joubert, LM, Haagensen, JA, Garcia, O., Malkovskiy, AV., Kaber, G, Nazik, H., Manasherob, R, Spormann, AM, Clemons, KV., Stevens, D.A, BollykyPL. 2016 MICROBIOLOGY.  DOI: 10.1099/mic.0.000344
  • 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. M Grandoch, U Flögel, S Virtue, JK Maier, T JelenikC Kohlmorgen, K Feldmann, Y Podsvyadek, TR. Castañeda, Z Zhou, Y Yamaguchi, EBM Nascimento, VG Sunkari, C Goy, M Kinzig, F Sörgel, PL Bollyky, P Schrauwen, H Al-Hasani, M Roden, S Keipert, A Vidal-Puig, M Jastroch, J Haendeler, JW Fischer. NATURE METABOLISM. 2019 April 22. doi.org/10.1038/s42255-019-0055-6
  • 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition. N Nagy, I Gurevich, HF Kuipers, SM Ruppert, PL Marshall, BJ Xie, W Sun, AV Malkovskiy, J Rajadas, M Grandoch, JW Fischer, AR Frymoyer, G Kaber, and PL Bollyky. JOURNAL OF BIOLOGICAL CHEMISTRY. 2019 Mar 26. pii: jbc.RA118.006166. doi: 10.1074/jbc.RA118.006166.
  • Lung-resident Tr1-like cells do not confer lasting tolerance to airway allergens. K Yadava*, CO Medina*, H Ishak, I Gurevich, HF Kuipers, EA Shamskhou, JJ Moon, C Weaver, G Ogg, K Nadeau, and PL Bollyky.  eLIFE. 2019 Oct 11. https://doi.org/10.7554/eLife.44821.001  * Co-first authors.
  • Hydrogel-based delivery of IL-10 improves treatment of bleomycin-induced lung fibrosis in mice. EA Shamskhou, MJ Kratochvil, ME Orcholski, N Nagy, G Kaber, E Steen, S Balaji, SG Keswani, B Danielson, K Yuan,, PL Bollyky*, and V De Jesus Perez*. BIOMATERIALS 2019; Feb 22 203;52-62 doi.org/10.1016/j.biomaterials.2019.02.017 *co-senior authors
  • Adenosine and hyaluronan modulate lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema (CPFE). Collum SD, Molina JG, Hanmandlu A, Bi W, Pedroza M, Mertens TCJ, Wareing N, Wei W, Wilson C, Sun W, Rajadas J, Bollyky PL, Philip KM, Ren D, Thandavarayan RA, Bruckner BA, Xia Y, Blackburn MR, Karmouty-Quintana H. DISEASE MODELS AND MECHANISMS. 2019 Apr 29. pii: dmm.038711. doi: 10.1242/dmm.038711
  • Quantitative Assessment of Bacterial Growth Phase Utilizing Flow Cytometry. KM Khomtchouk, M Weglarz, LA Bekale, PL Bollyky, and PL Santa Maria. JOURNAL OF MICROBIAL METHODS. 2019 Dec;167:105760. doi: 10.1016/j.mimet.2019.105760. PMID:31678132
  • X Wang, S Balaji, EH Steen, H Li, MM Rae, AJ Blum, MJ Butte, PL Bollyky, and SG Keswani.Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization and Extracellular Matrix Remodeling. ADVANCES IN WOUND CARE. 2019 Nov 1;8(11):527-537. doi: 10.1089/wound.2019.0981. PMID:31637099
  • Salivary hypothiocyanate as a novel biomarker of Cystic Fibrosis Transmembrane Regulator function. AV Malkovskiy, AA Yacob, CE Dunn, JM Zirbes, SP Ryan, PL Bollyky, J Rajadas, CE Milla. ANALYTICAL CHEMISTRY. 2019 Jun 18;91(12):7929-7934. doi: 10.1021/acs.analchem.9b01800. PMID:31117414
  • Beyond bacteria: perspectives of phage therapy in viral and fungal infections. A Górski, PL Bollyky, M Przybylski, J Borysowski, R Miedzybrodzki, E Jończyk-Matysiak, B Weber-Dąbrowska. FRONTIERS IN MICROBIOLOGY 2019 Jan 9;9:3306. doi: 10.3389/fmicb.2018.03306. PMID:30687285.  
  • Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System. JD Van Belleghem, K Dąbrowska, M Vaneechoutte, JJ Barr and PL Bollyky.VIRUSES 2019 Dec 25;11(1). pii: E10. doi: 10.3390/v11010010. PMID: 30585199

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