Publications

Selected Phage Immunology Publications

  • Filamentous Bacteriophages and the Competitive Interaction between Pseudomonas aeruginosa Strains under Antibiotic Treatment: a Modeling Study. Pourtois JD, Kratochvil MJ, Chen Q, Haddock NL, Burgener EB, De Leo GA, Bollyky PL. mSystems. 2021 Jun. PMID: 34156288
  • Bacteriophages and the Immune System. Popescu M, Van Belleghem JD, Khosravi A, Bollyky PL. ANNU REV VIROL. 2021 May. PMID: 34014761
  • Phage Therapy for Limb-threatening Prosthetic Knee Klebsiella pneumoniae Infection: Case Report and In Vitro Characterization of Anti-biofilm Activity. Cano EJ, Caflisch KM, Bollyky PL, Van Belleghem JD, Patel R, Fackler J, Brownstein MJ, Horne B, Biswas, Henry M, Malagon F, Lewallen DG, Suh GA. CLINICAL INFECTIOUS DISEASES. 2020 Jul. PMID: 32699879
  • Phages in vaccine design and immunity; mechanisms and mysteries. de Vries CR, Chen Q, Demirdjian S, Kaber G, Khosravi A, Liu D, Van Belleghem JD, Bollyky PL. CURR OPINION IN BIOTECHNOLOGY. 2020 Dec. PMID: 33316575
  • Pf bacteriophage and their Impact on Pseudomonas Virulence, Mammalian Immunity, and Chronic Infections. Secor PR, Burgener EB, Kinnersley M, Jennings LK, Roman-Cruz V,  Popescu M, Van Belleghem JD, Haddock N, Copeland C,  Michaels LM,  de Vries CD, Chen Q, Pourtos J,  Wheeler TJ ,Milla CE,  and Bollyky PL. FRONTIERS IN IMMUNOLOGY. 2020 Feb. PMID: 32153575
  • Filamentous Bacteriophage Suppress Clearance of Bacterial Infection. JM Sweere, J Van Bellegehem, H Ishak, MS Bach, M Popescu, V Sunkari, G Kaber, R Manasherob,GA Suh, X Cao,CR De Vries, DN Lam, PL Marshall, M Birukova, E Katznelson, DV Lazzareschi, S Balaji, S Keswani, TR Hawn, PR Secor, and PL Bollyky.. SCIENCE. (2019) 363, 6434, 1416. DOI: 10.1126/science.aat9691
  • Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in Cystic Fibrosis. EB Burgener, JM Sweere, MS Bach, PR Secor, N Haddock, LK Jennings, RL Marvig, HK Johansen, E Rossi, X Cao, L Tian, L Nedelec, S Molin, PL Bollyky* and CE Milla*  SCIENCE TRANSLATIONAL MEDICINE. 17 Apr 2019: Vol. 11, Issue 488, eaau9748 DOI: 10.1126/scitranslmed.aau9748   *co-senior authors
  • The innate sense of bacteriophages. Bollyky PL, Secor PR. CELL HOST & MICROBE. 2019 Feb 13;25(2):177-179. doi: 10.1016/j.chom.2019.01.020.
  • Macrophages and innate immune memory against Staphylococcus skin infections. Van Belleghem JD and Bollyky PL. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES.
  • Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System. Van Belleghem JD, Dąbrowska K, Vaneechoutte M, Barr JJ, Bollyky PL. VIRUSES. 2018 Dec 25;11(1). pii: E10. doi: 10.3390/v11010010.

Selected Biofilm Publications

  • Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media. Khomtchouk KM, Joseph LI, Khomtchouk BB, Kouhi A, Massa S, Xia A, Koliesnik I, Pletzer D, Bollyky PL, Santa Maria PL. NPJ BIOFILMS MICROBIOMES. 2021 Apr. PMID: 33824337
  • The Immune Response to Chronic Pseudomonas aeruginosa Wound Infection in Immunocompetent Mice. JM Sweere, H Ishak, V Sunkari, MS Bach, R Manasherob, K Yadava, SM Ruppert, CK Sen, S Balaji, SG Keswani, PR Secor, and PL Bollyky.  ADVANCES IN WOUND CARE.  2019 6 Aug 2019. doi.org/10.1089/wound.2019.1039
  • A Novel Mouse Model of Chronic Suppurative Otitis Media and its Use in Preclinical Evaluation of Antibiotics. Khomtchouk KM, Kouhi A, Xia A, Bekale LA, Massa SM, Sweere JM, Pletzer D, Hancock RE, Bollyky PL, Santa Maria PL.. SCIENCE ADVANCES. 2020 Aug. PMID: 32851190
  • Pf4 bacteriophage produced by Pseudomonas aeruginosa inhibits Aspergillus fumigatus metabolism via iron sequestration. Penner, JC., Ferreira, JA, Secor, PR, Sweere, JM, Birukova, M, Joubert, LM, Haagensen, JA, Garcia, O., Malkovskiy, AV., Kaber, G, Nazik, H., Manasherob, R, Spormann, AM, Clemons, KV., Stevens, D.A, BollykyPL. 2016 MICROBIOLOGY.  DOI: 10.1099/mic.0.000344
  • Filamentous Bacteriophage Promote Biofilm Assembly and Function.  Secor, PR, Sweere, JM, Michaels, LA, Malkovskiy, AV, Lazzareschi, D, Katznelson, E, Rajadas, J, Birnbaum, ME, Arrigoni, A, Braun, KR, Evanko, SP, Stevens, DA, Kaminsky, W, Singh, PK, Parks, WC, Bollyky, PL. CELL HOST & MICROBE. 2015; 18;5, 549-559. DOI 10.1016/Jchom.2015.10.013

Selected Extracellular Matrix Immunology Publications

  • Hyaluronan is abundant in COVID-19 respiratory secretions. Kaber G, Kratochvil MJ, Burgener EB, Peltan EL, Barlow G, Yang S, Nicolls MR, de Jesus Perez V, Rosser JI, Wardle AJ, Kalinowski A, Ozawa MG, Regula DP, Nagy N, Heilshorn SC, Milla CE, Rogers AJ, Bollyky PL.  BioRxiv Preprint. 2020 Sep. PMID: 32935110
  • Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection. Marshall PL, Nagy N, Kaber G, Barlow GL, Ramesh A, Xie BJ, Linde MH, Haddock NL, Lester CA, Tran QL, de Vries CR, Hargil A, Malkovskiy AV, Gurevich I, Martinez HA, Kuipers HF, Yadava K, Zhang X, Evanko SP, Gebe JA, Wang X, Vernon RB, de la Motte C, Wight TN, Engleman EG, Krams SM, Meyer EH, Bollyky PL. MATRIX BIOLOGY. 2021 Feb. PMID: 33290836
  • 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition. N Nagy, I Gurevich, HF Kuipers, SM Ruppert, PL Marshall, BJ Xie, W Sun, AV Malkovskiy, J Rajadas, M Grandoch, JW Fischer, AR Frymoyer, G Kaber, and PL Bollyky. JOURNAL OF BIOLOGICAL CHEMISTRY. 2019 Mar 26. pii: jbc.RA118.006166. doi: 10.1074/jbc.RA118.006166.
  • 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. M Grandoch, U Flögel, S Virtue, JK Maier, T JelenikC Kohlmorgen, K Feldmann, Y Podsvyadek, TR. Castañeda, Z Zhou, Y Yamaguchi, EBM Nascimento, VG Sunkari, C Goy, M Kinzig, F Sörgel, PL Bollyky, P Schrauwen, H Al-Hasani, M Roden, S Keipert, A Vidal-Puig, M Jastroch, J Haendeler, JW Fischer. NATURE METABOLISM. 2019 April 22. doi.org/10.1038/s42255-019-0055-6
  • Hydrogel-based delivery of IL-10 improves treatment of bleomycin-induced lung fibrosis in mice. EA Shamskhou, MJ Kratochvil, ME Orcholski, N Nagy, G Kaber, E Steen, S Balaji, SG Keswani, B Danielson, K Yuan,, PL Bollyky*, and V De Jesus Perez*. BIOMATERIALS 2019; Feb 22 203;52-62 doi.org/10.1016/j.biomaterials.2019.02.017 *co-senior authors
  • Adenosine and hyaluronan modulate lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema (CPFE). Collum SD, Molina JG, Hanmandlu A, Bi W, Pedroza M, Mertens TCJ, Wareing N, Wei W, Wilson C, Sun W, Rajadas J, Bollyky PL, Philip KM, Ren D, Thandavarayan RA, Bruckner BA, Xia Y, Blackburn MR, Karmouty-Quintana H. DISEASE MODELS AND MECHANISMS. 2019 Apr 29. pii: dmm.038711. doi: 10.1242/dmm.038711
  • Hyaluronan in immune dysregulation and autoimmune diseases. Nagy N, Kuipers HF, Marshall PL, Wang E, Kaber G, Bollyky PL. MATRIX BIOLOGY. 2018 Apr 4. pii: S0945-053X(17)30440-7. doi: 10.1016/j.matbio.2018.03.022
  • Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis. Collum, SD, Chen, NY, Hernandez, AM, Hanmandlu, A, Sweeney, H, Mertens, TCJ, Weng, T, Lou, F, Molina, JG, Davies, J, Horan, IP, Morrell, NW, Amione-Guerra, J, Al-Jabbari, O, Youker, K, Sun, W, Rajadas, J, Bollyky, PL, Akkanti, BH, Jyothula, S, Sinha, N, Guha, A, and H Karmouty-Quintara. BRITISH JOURNAL OF PHARMACOLOGY. 2017. DOI: 10.1111/bph.13947
  • Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. N Nagy, A de la Zerda, G Kaber, MJ Kratochvil, K Yadava, W Zhao, Y Cui, G Navarro, JP Annes, PY Johnson, KH Hu, CK Chan, TN Wight, SC Heilshorn, PL Bollyky*, MJ Butte*. JOURNAL OF BIOLOGICAL CHEMISTRY.  2017  *co-senior authors DOI: 10.1074/jbc.RA117.000148 
  • The phamacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice.  CLINICAL & EXPERIMENTAL IMMUNOLOGY. Kuipers, H.F., Nagy, N., Ruppert, S.M, Sunkari, VG,Marshall, PL, Gebe, JA, Ishak, HD, Keswani, SG, Bollyky, J,Frymoyer, AR, Wight, TN, Steinman, L, Bollyky, PL. 2016; 185 (3): 372-381. DOI: 10.1111/cei.12815
  • Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Kuipers, HF, Rieck, M, Gurevich, I, Nagy, N., Butte, MJ,Negrin, RS, Wight, TN, Steinman, L, Bollyky, PL. 2016. DOI: 10.1073/pnas.1525086113
  • 4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and canceFRONTIERS IN IMMUNOLOGY  Nagy, N, Kuipers, HK, Frymoyer, AR, Ishak, HD, Bollyky, JB, Wight, TN, Bollyky, PL. 2015; 6: 123. DOI 10.3389/fimmu.2015.00123 

Selected Immune Regulation Publications

  • Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice. Nagy N, Kaber G, Kratochvil MJ, Kuipers HF, Ruppert SM, Yadava K, Yang J, Heilshorn SC, Long SA, Pugliese A, Bollyky PL. DIABETOLOGIA. 2021 Jan. PMID: 33125521
  • Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, Meyer E, Piehler J, Leonard WJ, Garcia KC. eLIFE. 2021 May. PMID: 34003116
  • Lung-resident Tr1-like cells do not confer lasting tolerance to airway allergens. K Yadava*, CO Medina*, H Ishak, I Gurevich, HF Kuipers, EA Shamskhou, JJ Moon, C Weaver, G Ogg, K Nadeau, and PL Bollyky.  eLIFE. 2019 Oct 11. https://doi.org/10.7554/eLife.44821.001  * Co-first authors.
  • The Heparan Sulfate Mimetic PG545 polarizes T-cell responses towards Foxp3+ Treg. Koliesnik IO, Kuipers HF, Medina CO, Zihsler S, Liu D, Van Belleghem JD, Bollyky PL. FRONTIERS IN IMMUNOLOGY. 2020 Feb. PMID: 32117279
  • Inhibition of hyaluronan synthesis restores immune tolerance during autioimmune insulitis.  JOURNAL OF CLINICAL INVESTIGATION Nagy, N, Kaber, G, Johnson, PY, Gebe, JA, Preisinger, A, Falk, BA, Sunkari, VG, Gooden, MD, Vernon, RB, Bogdani, M, Kuipers, HF, Day, AJ, Campbell, DJ, Wight, TN, Bollyky, PL. 2015 DOI 10.1172/JCI79271
  • Low-Dose Antigen Promotes Induction of FOXP3 in Human CD4(+) T Cells. JOURNAL OF IMMUNOLOGY. Long, SA, Rieck, M, Tatum, M, Bollyky, PL, Wu, RP, Muller, I, Ho, J, Shilling, HG, Buckner, JH. 2011; 187 (7): 3511-3520.  DOI 10.4049/jimmunol.1003880
  • ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES Bollyky, PL, Wu, RP, Falk, BA, Lord, J D., Long, SA, Preisinger, A, Teng, B., Holt, GE, Standifer, NE, Braun, KR, Xie, C. F., Samuels, PL, Vernon, RB,Gebe, JA, Wight, TN, Nepom, GT 2011; 108 (19): 7938-7943.   DOI 10.1073/pnas.1017360108
%d bloggers like this: