Research

Welcome to the Bollyky Lab Website!   We are a translational immunology lab in the Division of Infectious Diseases at Stanford University.

Our lab studies the innate immune response to injury and infection.  Many of our projects focus on Pseudomonas aeruginosa infections of airways and diabetic wounds.  Our goals are to gain insight into fundamental disease mechanisms and to generate novel therapies to improve human health.

One area of active research involves bacteriophages – viruses that infect bacteria. The human body contains more bacteriophages than human cells but their impact on human biology is largely unknown. Current efforts are focused on understanding how bacteriophage interact with mammalian cells, how this infection influences local immunity, and how phage shape the immune response to commensal and pathogenic bacteria. We also have active efforts involved in characterizing the “phageome” – the collection of phages present in the body.

A second area of active research involves biofilms – the communities of polymers and bacteria that colonize infected tissues. The extracellular matrix present in biofilms exerts important but poorly understood effects on chronic infection. We are interested in how biofilms modulate human immunity, prevent diffusion of antibiotics, and contribute to chronic infection.

A third area of investigation is the tissue extracellular matrix at sites of injury and infection. In particular, we are interested in the roles that hyaluronan and other extracellular matrix polymers play in immune regulation  in diabetes and diabetic wound infection.

Looking for a lab?  

We are actively recruiting structural biologists, biochemists, immunologists, and microbiologists for post-doctoral positions in the lab. If interested, please contact Dr. Bollyky at pbollyky@stanford.edu

For Stanford Undergraduates interested in joining the lab, we require a minimum commitment of a full year (including full-time work in the lab for at least one summer).

We take high school and undergraduate students through the SSRP program: https://biosciences.stanford.edu/prospective/diversity/ssrp/

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